Dr. Rikesh Kumar Dubey

Dr. Rikesh Kumar Dubey

Assistant Professor
Qualification : Ph.D.
Email : rikeshkd@srmist.edu.in; rikesh.cdri@gmail.com
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Dr. Rikesh Kumar Dubey’s research centers on the pathophysiology of sickle cell disease and other hematological disorders characterized by vascular and thrombo-inflammatory complications, including polycythemia. His work focuses on sterile inflammation, platelet activation, mitochondrial dysfunction, and endothelial cell biology to understand mechanisms underlying vascular complications. He explores molecular pathways driving thrombo-inflammatory responses and aims to identify novel translational therapeutic targets. He is actively involved in biomarker discovery and the development of inflammation-driven disease models with an emphasis on translational and clinical applicability.

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Dr. Rikesh Kumar Dubey’s research centers on the pathophysiology of sickle cell disease and other hematological disorders characterized by vascular and thrombo-inflammatory complications, including polycythemia. His work focuses on sterile inflammation, platelet activation, mitochondrial dysfunction, and endothelial cell biology to understand mechanisms underlying vascular complications. He explores molecular pathways driving thrombo-inflammatory responses and aims to identify novel translational therapeutic targets. He is actively involved in biomarker discovery and the development of inflammation-driven disease models with an emphasis on translational and clinical applicability.

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Degree Year of Passing Name of College & University
Ph.D (Biological Sciences) (2015-2020) Jawaharlal Nehru University, New Delhi, India
CSIR-Central Drug Research Institute, Lucknow, UP, India
M.Sc Applied Microbiology (2011-2013) Banaras Hindu University, Varanasi, UP, India
B.Sc (Hons.) Microbiology (2008-2011) Bundelkhand University, Jhansi, UP, India
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Degree Year of Passing Name of College & University
Ph.D (Biological Sciences) (2015-2020) Jawaharlal Nehru University, New Delhi, India
CSIR-Central Drug Research Institute, Lucknow, UP, India
M.Sc Applied Microbiology (2011-2013) Banaras Hindu University, Varanasi, UP, India
B.Sc (Hons.) Microbiology (2008-2011) Bundelkhand University, Jhansi, UP, India
Designation Institution From To
Assistant Professor SRM Institute of Science and Technology, Kattankulathur, TN, India 2025 till
Postdoctoral Fellow Versiti Blood Research Institute, Milwaukee, WI, USA. 2023 2025
Postdoctoral Associate University of Pittsburgh School of Medicine, Pittsburgh, PA,  USA 2020 2023

Sickle cell disease, Platelet biology, Polycythemia, Sterile inflammation, Host-pathogen interaction.

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  • Kaminski TW, Katoch O, Li Z, Hanway CB, Dubey RK (….),Sundd TP, 2023. Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease, 2023 Nov 9. doi: 10.3324/haematol.2023.283792 Haematologica (IF 10.5).
  • Vats R, Ungalara R, Dubey RK, Sundd P, Pradhan-Sundd T. Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice. Cells. 2025 Jan 28;14(3):194. doi: 10.3390/cells14030194. PMID: 39936985; PMCID: PMC11817884. (IF 5.2)
  • Kaminski TW, Brzoska T, Li X, Vats R, Katoch O, Dubey RK, Bagale K, Watkins SC, McVerry BJ, Pradhan-Sundd T, Zhang L, Robinson KM, Nyunoya T, Sundd P. Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke induced severe flu. JCI Insight. 2023 Dec 7:e167299. doi: 10.1172/jci.insight.167299. Epub ahead of print. PMID: 38060312. (IF 8.0)
  • Dubey RK, Vats R, Brzoska T, Kaminski TW, Katoch O, Tejero J, Njikang G, Paderi J, Sundd P (2023). Subcutaneous injection of IHP102 prevents lung vaso-occlusion in Sickle Cell Disease mice. Haematologica. 2023 Oct 19. doi: 10.3324/haematol.2023.283716 (IF 10.5)
  • Kaminski TW, Sivanantham A, Mozhenkova A, Smith A, Ungalara R, Dubey RK, Shrestha B, Hanway C, Katoch O, Tejero J, Sundd P, Novelli EM, Kato GJ, and Pradhan-Sundd T (2024). Hemoglobin scavenger receptor CD163 as a potential biomarker of hemolysis induced hepatobiliary injury in sickle cell disease. American Journal of Physiol Cell Physiol. 29 APR 2024 doi.org/10.1152/ajpcell.00386.2023 (IF 5.5)
  • Kaminski TW, Ju EM, Gudapati S, Vats R, Arshad S, Dubey RK, Katoch O, Tutuncuoglu E, Frank J, Brzoska T, Stolz DB, Watkins SC, Chan SY, Ragni MV, Novelli EM, Sundd P, Pradhan-Sundd T.(2022) Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice. Blood Advances. Jun 28;6(12):3729-3734. doi: 10.1182/bloodadvances.2021006388. (IF 7.63)
  • Dubey RK*. Assuming the role of mitochondria in mycobacterial infection. J. Mycobacteriol 2016; 5(4): 379–383. doi:10.1016/j.ijmyco.2016.06.001 (IF-1.21)
  • Dubey R.K*., Narain A. (2021) Antimycobacterial Attributes of Mitochondria: An Insight into Host Defense Mechanisms. In: Karakousis P.C., Hafner R., Gennaro M.L. (eds) Advances in Host-Directed Therapies Against Tuberculosis. Springer, Cham. https://doi.org/10.1007/978-3-030-56905-1_9 (*Corresponding author)
  • Apoorva Narain, Surya Kant, Rikesh K Dubey, Kanchan Srivastava and Anand Kumar Maurya (2020). Proteome Based Insights in Drug-Resistant Mycobacterium tuberculosis - Pp. 204-217 (14). Microbial Proteomics: Development In Technologies And Applications. Bentham Books. https://benthambooks.com/book/9789811491412
  • Narain, A., Dubey, R.K*. (2025). The Emerging Role of CAR-NK Cells: Next-Generation Cancer Immunotherapy. In: Mishra, A.K., Malonia, S.K. (eds) Cell-based Immunotherapies forCancer. Springer,Cham.https://doi.org/10.1007/978-3-031-88695-9_12(*Corresponding author)
  • Dubey RK, Dhamija E, Kumar Mishra A, Soam D, Mohanrao Yabaji S, Srivastava K, Srivastava KK. Mycobacterial origin protein Rv0674 localizes into mitochondria, interacts with D-loop and regulates OXPHOS for intracellular persistence of Mycobacterium tuberculosis. Mitochondrion. 2021 Mar;57:241-256. doi: 10.1016/j.mito.2020.11.014. Epub 2020 Dec 3. PMID: 33279599. (IF 4.5)
  • Narain A, Dubey RK, Verma AK, Srivastava A, Kant S. Potential Role of Proteasome Accessory Factor-C in Resistance against Second Line Drugs in Mycobacteria. J Lab Physicians 2020 ;12 (4):250-262. doi: 10.1055/s-0040-1722552. (IF 1.2)
  • Mishra AK, Shivraj M Yabaji, Dubey RK, Dhamija E, Srivastava KK. Dual Phosphorylation of Response Regulator Protein PrrA is the Key Signature for the Increased Intracellular Survival of Mycobacteria Consequent upon Transcriptional Biochem J 2017; 474(24):4119-4136. doi: 10.1042/BCJ20170596. (IF-3.7)
  • Yabaji SM, Mishra AK, Chatterjee A, Dubey RK, Srivastava K, Srivastava KK. Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK. Biochem Biophys Res Commun 2017; 494(3-4):433-439. doi:10.1016/j.bbrc.2017.10.055 (IF-3.3)
  • Mishra AK, Yabaji SM, Dubey RK (2018). Evaluation of Isoprinosine to be repurposed as an adjunct anti-tuberculosis chemotherapy. Med Hypotheses 2018; 115:77-80. doi:10.1016/j.mehy.2018.04.002 (IF-4.4)
  • A Mishra, R Dubey, S Yabaji, Swati Jaiswal (2016). Evaluation of antimycobacterial rhamnolipid production from non-cytotoxic strains of Pseudomonas aeruginosa isolated from rhizospheric soil of medicinal plants. International Journal of Biological Research. 4(2):112 118. DOI: 10.14419/ijbr.v4i2.6429

‪RIKESH KUMAR DUBEY, Ph.D. - ‪Google Scholar

Poster/Oral Presentations/Conference Proceedings:

  • Rikesh K Dubey, Alok K Mishra, Shivraj M Yabaji and Kishore K Srivastava.Mitochondrial arbitration in intracellular survival of mycobacteria. International meetings on cell biology of Infection, NCBS Bangalore (2016).
  • Rikesh K Dubey, Alok K Mishra, Shivraj M Yabaji and Kishore K Srivastava.Regulation of Mitochondrial Proteins during Intracellular Survival of Mycobacteria. Mitochondria in Health and Disease, JNU, New Delhi (2017).
  • Rikesh K Dubey, Dheeraj Soam, Ekta Dhamija, Shivraj M Yabaji, Alok K Mishra, Kanchan Srivastava and Kishore K Srivastava. Delineation of the function of a mitochondrial translocated hypothetical protein of mycobacteria which regulates oxidative phosphorylation of infected macrophage. XLII All India Cell Biology Conference, BITS Pilani, Goa (2018).
  • Rikesh K Dubey, Ekta Dhamija, Alok K Mishra, Dheeraj Soam, Shivraj M Yabaji, Kanchan Srivastava and Kishore K Srivastava. A mycobacterial encoded hypothetical protein is localized in mitochondria and regulates oxidative phosphorylation of infected macrophage. ERS International Congress, Madrid, Spain (2019).
  • Tomasz W. Kaminski, Tomasz Brzoska, Xiuying Li, Ravi Vats, Rikesh K. Dubey, Kara Nickolich, Keven Robinson, Toru Nyunoya, Prithu Sundd: Platelet-rich Neutrophil-platelet Micro-emboli Contribute to Cigarette Smoke-induced Influenza Severity. ISTH 2021 Congress; Res Pract Thromb Haemost. 2021; 5 (Suppl 1)
  • Rikesh K. Dubey, Tomasz Kaminski, Tomasz Brzoska , Omika Katoch, Prithu Sundd. Platelet TLR9 promotes pulmonary thrombo-inflammation in sickle cell disease. Pittsburgh International Lung Conference, Pittsburgh, PA, USA (2022)
  • Ravi Vats, Rikesh K Dubey# , Gabriel Njikang, John Paderi, Prithu Sundd. Subcutaneous Injection of IHP-102 Attenuates Lung Vaso-Occlusion in Sickle Cell Disease Mice. 64th American Society of Hematology meeting 2022 (ASH-2022), New Orleans, Louisiana, USA ( # Presenting Author)
  • Rikesh K Dubey, Ravi Vats, Omika Katoch, Gabriel Njikang, John Paderi, Prithu Sundd. DOM Research Day (2023), University of Pittsburgh, Pittsburgh, PA, USA. 
  • Rikesh K Dubey, Omika Katoch, Enrico M Novelli, Prithu Sundd. Circulating NETs Promote Platelet-TLR9 Dependent Acute Chest Syndrome in Sickle Cell Disease. American Society of Hematology meeting 2023 (ASH-2023), San Diego, California, USA
  • Rikesh K Dubey, Omika Katoch, Prithu Sundd. Platelet-nucleic acid receptor promotes pulmonary thrombo-inflammation in sickle cell disease, (2024), Thrombosis and Hemostasis Summit of North America (THSNA), Chicago, Illinois, USA.
  • Rikesh K Dubey, Omika Katoch, Prithu Sundd. Platelet-TLR9 promotes acute lung injury in sickle cell disease (2024), Annual Retreat VBRI, Milwaukee, Wisconsin, USA
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Funded Projects

  • Title : Uncovering the impact of elevated hemoglobin: cellular and molecular insight into preclinical endothelial stress and genetic determinants of elevated hemoglobin.
    Role: PI/Co-PI: Principal Investigator (PI)
    Funding Agency :  GATE Research Grant, SRMIST, Kattankulathur
    Year & Duration : 2026-28  (ongoing)
    Sanctioned Amount: Rs. 5,00,000
  • Title : Platelet TL9 in promoting vaso-occlusion in SCD
    Role: PI/Co-PI: Principal Investigator (PI)
    Funding Agency: The Histochemical Society, USA
    Year & Duration : 2023-24  (completed)
    Sanctioned Amount: $4000
  • Title: TLR9 positive platelet extracellular vesicles promote acute chest syndrome in sickle cell disease
    Role: PI/Co-PI: Principal Investigator (PI)
    Funding Agency: Hemostasis and Thrombosis Research Society,  USA.
    Year & Duration : 2024-25  (completed)
    Sanctioned Amount: $7500

Publications

  • Dubey RK, Dhamija E, Mishra AK, Soam D, Yabaji SM, Srivastava K, Srivastava KK Mycobacterial origin protein Rv0674 localizes into mitochondria, interacts with D-loop and regulates OXPHOS for intracellular persistence of Mycobacterium tuberculosis (2020). doi: 10.1016/j.mito.2020.11.014
  • Narain A, Dubey RK, Verma AK, Srivastava A, Kant S. Potential Role of Proteasome Accessory Factor-C in Resistance against Second Line Drugs in Mycobacteria. J Lab Physicians 2020 ;12 (4):250-262. doi: 10.1055/s-0040-1722552.
  • Mishra AK, Shivraj M Yabaji, Dubey RK, Dhamija E, Srivastava KK. Dual Phosphorylation of Response Regulator Protein PrrA is the Key Signature for the Increased Intracellular Survival of Mycobacteria Consequent upon Transcriptional Activation. Biochem J 2017; 474(24):4119-4136. doi: 10.1042/BCJ20170596.
  • Yabaji SM, Mishra AK, Chatterjee A, Dubey RK, Srivastava K, Srivastava KK. Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK. Biochem Biophys Res Commun 2017; 494(3-4):433-439. doi:1016/j.bbrc.2017.10.055
  • Mishra AK, Yabaji SM, Dubey RK (2018). Evaluation of Isoprinosine to be repurposed as an adjunct anti-tuberculosis chemotherapy. Med Hypotheses 2018; 115:77-80. doi:10.1016/j.mehy.2018.04.002
  • Dubey RK*. Assuming the role of mitochondria in mycobacterial infection. J. Mycobacteriol 2016; 5(4): 379–383. doi:10.1016/j.ijmyco.2016.06.001 (*Corresponding author)
  • A Mishra, R Dubey, S Yabaji, Swati Jaiswal (2016). Evaluation of antimycobacterial rhamnolipid production from non-cytotoxic strains of Pseudomonas aeruginosa isolated from rhizospheric soil of medicinal plants. International Journal of Biological Research. 4(2):112 118. DOI: 10.14419/ijbr.v4i2.6429
  • Dubey R.K*., Narain A. (2021) Antimycobacterial Attributes of Mitochondria: An Insight into Host Defense Mechanisms. In: Karakousis P.C., Hafner R., Gennaro M.L. (eds) Advances in Host-Directed Therapies Against Tuberculosis. Springer, Cham. https://doi.org/10.1007/978-3-030-56905-1_9 (*Corresponding author)
  • Narain A, Kant S, Dubey RK, Srivastava K and Maurya AK (2020). Proteome Based Insights in Drug-Resistant Mycobacterium tuberculosis - Pp. 204-217 (14). Microbial Proteomics: Development In Technologies And Applications. Bentham Books. https://benthambooks.com/book/9789811491412
  • Kaminski TW, Brzoska T, Li X, Vats R, Katoch O, Dubey RK, Bagale K, Watkins SC, McVerry BJ, Pradhan-Sundd T, Zhang L, Robinson KM, Nyunoya T, Sundd P. Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke induced severe flu. JCI Insight. 2023 Dec 7:e167299. doi: 10.1172/jci.insight.167299. Epub ahead of print. PMID: 38060312.
  • Dubey RK, Vats R, Gentinetta T, (..) J. Kato, Paolo Rossato, Gerald Hoebarth, Prithu Sundd. Acute therapy with hemopexin (CSL889) resolves LPS-induced lung vaso-occlusion in sickle mice. Blood VTH. 2026. 10.1016/j.bvth.2026.100189
  • Dubey RK, Vats R, Brzoska T, Kaminski TW, Katoch O, Tejero J, Njikang G, Paderi J, Sundd P (2023). Subcutaneous injection of IHP102 prevents lung vaso-occlusion in Sickle Cell Disease mice. Haematologica. 2023 Oct 19. doi: 10.3324/haematol.2023.283716
  • Vats R, Ungalara R, Dubey RK, Sundd P, Pradhan-Sundd T. Heme-Oxygenase Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice. Cells. 2025 Jan 28;14(3):194. doi: 10.3390/cells14030194. PMID: 39936985; PMCID: PMC11817884.
  • Kaminski TW, Katoch O, Li Z, Hanway CB, Dubey RK (….),Sundd TP, Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease,  2023 Nov 9. doi: 10.3324/haematol.2023.283792 Haematologica.
  • Kaminski TW, Sivanantham A, Mozhenkova A, Smith A, Ungalara R, Dubey RK, Shrestha B, Hanway C, Katoch O, Tejero J, Sundd P, Novelli EM, Kato GJ, and Pradhan-Sundd T (2024). Hemoglobin scavenger receptor CD163 as a potential biomarker of hemolysis induced hepatobiliary injury in sickle cell disease. American Journal of Physiol Cell Physiol. 29 APR 2024 doi.org/10.1152/ajpcell.00386.2023
  • Vats R, Li Z, Ju EM, Dubey RK, Kaminski TW, Watkins S, Pradhan-Sundd T (2022). Intravital imaging reveals inflammation as a dominant pathophysiology of age-related hepatovascular changes. American Journal of Physiol Cell Physiol. Mar 1;322(3): C508-C520. doi:10.1152/ajpcell.00408.2021.
  • Kaminski TW, Ju EM, Gudapati S, Vats R, Arshad S, Dubey RK, Katoch O, Tutuncuoglu E, Frank J, Brzoska T, Stolz DB, Watkins SC, Chan SY, Ragni MV, Novelli EM, Sundd P, Pradhan-Sundd T.(2022) Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice. Blood Advances. Jun 28;6(12):3729-3734. doi: 10.1182/bloodadvances.2021006388. (IF 7.63)
  • Tina Rubic-Schneider, Tomasz W Kaminski, David Ledieu, Déborah Garcia, Jeannine Hehlen, Coline Burnet-Merlin, Benjamin Cochin de Billy, Barbara Greutmann, Anthony M DeLise, Tomasz Brzoska, Renee Bergeron, Rikesh K Dubey, Tirthadipa Pradhan-Sundd, Frieder Krӧner, Mélanie Verneret, Andreas Bruederle, Patrick C Hines, Xiufeng Gao, Maya Dajee, Prithu Sundd. Crizanlizumab and inclacumab are equally potent inhibitors of cell adhesion in the blood of patients with sickle cell disease. Blood Red Cells & Iron. 2025
  • Narain, A., Dubey, R.K*. (2025). The Emerging Role of CAR-NK Cells: Next-Generation Cancer Immunotherapy. In: Mishra, A.K., Malonia, S.K. (eds) Cell-based Immunotherapies forCancer. Springer,Cham.https://doi.org/10.1007/978-3-031-88695-9_12 (*Corresponding author)
  •  Dubey RK*, Narain A. Beyond hemoglobin polymerization: Mitochondrial pathobiology and therapeutic frontiers in sickle cell disease. Int J Biochem Cell Biol. 2026 Aug-Sep;197-198:106943. doi: 10.1016/j.biocel.2026.106943. Epub 2026 Apr 8. PMID: 41956355. (*Corresponding author)
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  • Senior Research Fellow awarded by Council of Scientific and Industrial Research (CSIR) from January 2017 to December 2019
  • National Eligibility Tests qualified (a) CSIR-NET (Life Sciences) Junior Research Fellowship, 2014 (AIR-49th)
  • (b) ICAR-NET (Agri. Microbiology), 2014
  • Qualified National level Graduate Aptitude Test in Engineering (GATE-2014) conducted by Indian Institute of Technology (IIT), Roorkee
  • DST-SERB International travel grant to attend ERS International Congress 2019 held in Madrid, Spain from 28th Sep to 2nd Oct 2019.
  • NRI Young Scientist Award- 2023 awarded by The Microbiologists Society, India
  • Education Committee Travel Award-2024 by Versiti Wisconsin Inc, USA.
  • International Advisory Committee member for 64th Annual International Conference of the Association of Microbiologists of India (AMI)-2023, Jhansi, UP, India.
  • Member of Social Committee (2023-24) at Versiti Blood Research Institute, Milwaukee, WI, USA.
  • Served as Judge for Poster Session at University of Pittsburgh Postdoctoral Association (UPPDA)-Data and Dine Symposium (2022), Pittsburgh, PA, USA
  • Served as Judge for Poster Session for Health Disparities and Social Justice Poster Competition (2023), Pittsburgh, PA, USA.
  • Advisor (2022-23) at Pittsburgh Cricket League, University of Pittsburgh, Pittsburgh, PA, USA
  • 12. Member of Budget Senate Committee (2022- 23) at Postdoctoral Association at University of Pittsburgh, USA
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  • Senior Research Fellow awarded by Council of Scientific and Industrial Research (CSIR) from January 2017 to December 2019
  • National Eligibility Tests qualified
    (a) CSIR-NET (Life Sciences) Junior Research Fellowship, 2014 (AIR-49th)
    (b) ICAR-NET (Agri. Microbiology), 2014
  • Qualified National level Graduate Aptitude Test in Engineering (GATE-2014) conducted by Indian Institute of Technology (IIT), Roorkee
  • DST-SERB International travel grant to attend ERS International Congress 2019 held in Madrid, Spain from 28th Sep to 2nd Oct 2019.
  • NRI Young Scientist Award- 2023 awarded by The Microbiologists Society, India
  • Education Committee Travel Award-2024 by Versiti Wisconsin Inc, USA.
  • International Advisory Committee member for 64th Annual International Conference of the Association of Microbiologists of India (AMI)-2023, Jhansi, UP, India.
  • Invited Resource Person- DHR training at ICMR-CRMCH, ICMR-NIIH, Mumbai, 2026
  • Invited Resource Person for faculty development program at The Neotia University, Kolkata, 2026
  • Organizing Committee Member for National Science Day, SRMIST, Kattankulathur, 2026
  • Member of Social Committee at Versiti Blood Research Institute, Milwaukee, WI, USA.
  • Served as Judge for Poster Session at University of Pittsburgh Postdoctoral Association (UPPDA)-Data and Dine Symposium (2022), Pittsburgh, PA, USA
  • Served as Judge for Poster Session for Health Disparities and Social Justice Poster Competition (2023), Pittsburgh, PA, USA.
  • Review Editor- Microbial Physiology and Metabolism in Frontiers in Microbiology (2023)
  • Review Editor- Antimicrobials, Resistance, and Chemotherapy in Frontiers in Microbiology (2023)
  • Review Editor- Pathogenesis, vaccines, and Immunity of Bacterial infections in Frontiers in Bacteriology
  • Research Topic Coordinator- Frontiers in Cellular and Infection Microbiology (2023)

PhD Scholars

  • Name: Ms. Anushka Das
    Email: ad7164@srmist.edu.in
    Education: M.Sc Biotechnology
    Area of interest: Platelet biology
  • Name: Mr. Uttam Mrityunjay Mani Tiwari
    Email: um9115@srmist..edu.in
    Education: M.Sc Biotechnology
    Area of Interest: Polycythemia

Availability: Currently not available