Dr. Gisha Sivan is an Assistant Professor (Research) in the Department of Medical Research at SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur. A toxicologist by training, her primary research focuses on microplastics and emerging contaminants and their impact on human health, particularly respiratory, cardiovascular and reproductive health. She uses zebrafish as a disease model to understand how environmental pollutants affect organ systems, gut microbiota and disease mechanisms. Her work applies adverse outcome pathway approaches to identify toxic endpoints and molecular mechanisms, strengthening risk assessment. Her study connects experimental findings with human health outcomes in environmental and biomedical research.
- PhD - Cochin University of Science and Technology, Kerala, India – 2008
- Assistant Professor (Research) – 2023- Division of Medical Research -Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Tamil Nadu, India
- Academic Counsellor - 2021 -23 – BSCG, IGNOU study center, Sacred Heart College, Thevara, India
- Lecturer – 2018-2021 Department of Zoology, Sacred Heart College, Thevara, India
- Lecturer - 2016- 2018 Post-graduate Research Department, St Alberts College, Ernakulam, India
- Postdoctoral Fellow -2012-2015 Department of Biochemistry, University of Madras, Chennai, India
- CSIR RA – 2010 -2012 Division of Biology, Indian Institute of Chemical Technology, Tarnaka, Secunderabad, Andhra Pradesh, India.
- MicroNanoplastic toxicity, Emerging Contaminants, Adverse Outcome Pathway
Funded Projects
Title: Safety and Effectiveness of Homeopathy as an Add- on Treatment to Standard Care in the Management of Cardiac Arrhythmia
Role: CoPI / Project Coordinator
Funding Agency: CCRH
Year & Duration: 3 years
Sanctioned Amount: Rs 1,04,000,00
Publications
- Pamanji R, Kumareshan TN, Lakshmi Priya S, Sivan G, Selvin J. Unravelling the Impact of Antibiotics, Microplastics, Nanoparticles, Pesticides, and other various Chemical entities on Gut Microbiota of Zebrafish. Chemosphere. 2024 Feb; 349:140867. doi: 10.1016/j.chemosphere.2023.140867
- Sivan G, Pamanji R, Selvin J. Zebrafish model for Parkinson’s disease. Chapter 21, Taylor & Francis / CRC Press. 2024 Sep; ISBN 9781032515779
- Sivan G, Rajesh Pamanji, Srikanth Koigoora, Nimila Joseph, Joseph Selvin. In vivo toxicological assessment of silver nanoparticle in edible fish, Oreochromis mossambicus. Toxicology Research. 2024 Feb; 13(1):tfae019. doi: 10.1093/toxres/tfae019
- Nair MC, Stanley L, Sivan G, et al. To compare the HOMA-IR and metabolic profile in lean and obese subjects with non-alcoholic fatty liver disease. Egypt Liver Journal. 2024; 14:38. doi: 10.1186/s43066-024-00341-8
- Paul A, Gnanamoorthy K, Sivan G, Kumar JS. Prevalence of diabetic cheiroarthropathy and its association with macrovascular complications: A cross-sectional study. Rheumatology & Autoimmunity. 2024; doi: 10.1002/rai2.12138
- Rajesh Pamanji, Prathiviraj Ragothaman, Srikanth Koigoora, Sivan G, Joseph Selvin. Network Analysis of Toxic endpoints of Fungicide in Zebrafish. Journal of Toxicology Research. 2024; doi: 10.1093/toxres/tfae087
- Sivan G, Rajesh Pamanji, Srikanth Koigoora. Sensitive to organs or sensitivity of analytical equipment?. Journal of Hazardous Materials. 2024 May; 474:134722. doi: 10.1016/j.jhazmat.2024.134722
- Dev A, R NK, K A, Sivan G, Rajesh Lenin R, Kumar JS. Correlation of Mean Platelet Volume and Red Cell Distribution width with HbA1c and its Association with Microvascular Complications in Type 2 Diabetes Mellitus: A Cross-Sectional Study at a Tertiary Hospital in India. Cureus. 2024 Aug; 16(8):e66139. doi: 10.7759/cureus.66139
- Pavithran M, K P, P K, Sivan G, et al. Larger Airway Functions in Poultry and Dairy Confinement Workers: A Cross-Sectional Study. Cureus. 2024 Oct; 16(10):e71045. doi: 10.7759/cureus.71045
- Rajesh Pamanji, Sivan G. Toxic Endpoints or Ubiquitous Expression?. Toxicology Research. 2025;
- Koigoora Srikanth, Sadhanala Siksha Sravani, Rajesh Pamanji, Nadiya Shaik, Sivan G, Nadakuditi Venkata Raju. Cigarette Butts: A Source of Toxicity and Potential Disruption of Pila virens Antioxidant Mechanisms. Toxicology Research. 2025;
- Pamanji R, Prathiviraj R, Sivan G. Multi-Omics Integration In to Adverse Outcome Pathway Framework: Principles, Progress, and Prospects for Next-Generation Toxicological Risk Assessment. Environmental and Molecular Mutagenesis. 2026; 67(5-7):e70068. doi: 10.1002/em.70068
- Pamanji R, Sivan G. Pesticide bioavailability, bioaccumulation, and bioconcentration in zebrafish: a critical review with emphasis on methodological inadequacies. Archives of Toxicology. 2026; doi: 10.1007/s00204-026-04389-w
- Rajesh Pamanji, Srikanth Koigoora, Gisha Sivan. MicroRNAs as Bridging Key Events in Zebrafish Cardiovascular Adverse Outcome Pathways: A Cross-Chemical Evidence Synthesis and the miR-BKE Framework. Environmental Toxicology and Chemistry. 2026; vgag254. doi: 10.1093/etojnl/vgag254
- INSA NASI IAS Summer faculty fellowship 2024
PhD Scholars
- Name: Swetha P
Email:sp8373@srmist.edu.in
Education: MSc Microbiology
Area of interest: Microplastic toxicity - Name: Soniya B
Email: sb1616@srmist.edu.in
Education: MSc Zoology
Area of interest: Microplastic toxicity - Name: Rishi Kumar N
Email: rn6500@srmist.edu.in
Education: MSc Biotechnology
Area of interest: Microplastic toxicity
Availability: Available
Research Area: Nanoparticle synthesis
Number of Positions: 1
Eligibility / Preferred Background: Biochemistry
Mode of Registration: Full-time
