Dr. Mrinmoy Das

• Allergic and inflammatory diseases: atopic dermatitis, asthma, allergic rhinitis, COPD, and food allergy
• Epithelial barrier dysfunction, IgE-mediated immunity, and basophil biology
• Host-pathogen interactions and susceptibility to respiratory infections (URTI & LRTI)
• Skin-gut immune axis and T cell trafficking
• Translational immunology, environmental triggers, and biomarker discovery

2026

1. Das M #, Geha RS. Basophils in atopic dermatitis: Immunologic roles and clinical implications. Ann Allergy Asthma Immunol. 2026 Feb;136(2):149-157. (# corresponding author)
2. Mokal CN, Das M, Hannenhalli S, Agrawal P. Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics, and computational advances. Front Cell Dev Biol. 2026 Jan 22;13:1754209. 

2025

1. Das M#, Alasharee M, Woods B, Mukherjee S, Kim S, Elkins M, Ngo J, Magin L, Timilshina M, Leyva-Castillo JM, Murphy KM, Anthony RM, Laureano AFS, Murphy GF, McNamee S, Brombacher F, Hogan SP, Turner JR, Abtahi S, Phipatanakul W, Leung DYM, Goleva E, Oettgen HC, Li M, Chou J, Schlievert PM, Finkelman FD, Geha RS. S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis. Immunity. 2025 Nov 11;58(11):2769-2784.e6. (# corresponding author)
2. Mukherjee S, Geha RS, Das M#. The Mechanisms of Immunoglobulin E Sensitizations in Atopic Dermatitis. Immunol Allergy Clin North Am. 2025 Nov;45(4):535-546. (# corresponding author)
3. Janssen E*, Das M*, Butts J, Alasharee M, Mukherjee S, Lozano GL, Rao C, Livingston AF, Woods B, Smith E, Peters Z, Milin E, Beamer MA, Wilkie H, Leyva-Castillo JM, Kam C, Sobh A, Dasouki M, Wakim RH, Dbaibo G, Al-Herz W, Chatila TA, Finkelman FD, Rakoff-Nahoum S, Geha RS. DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis. Immunity. 2025 Jul 8;58(7):1794-1810.(* Co-first authors)
4. Chakraborty S, Banerjee P, Joseph JP, Pathak S, Verma T, Karhale AK, Chandra D, Das M, Saha P, Nandi D. Functional loss of rffG and rfbB, encoding dTDP-glucose 4,6-dehydratase, alters colony morphology, cell shape, motility and virulence in Salmonella Typhimurium. Front Microbiol. 2025 May 21;16:1572117.
5. Das M, Keswani T. Editorial: T and B cell immune dynamics in allergic response. Front Allergy. 2025 Feb 12;6:1558724. 
6. Conrad ML, Barrientos G, Cai X, Mukherjee S, Das M, Stephen-Victor E, Harb H. Regulatory T cells and their role in allergic disease. Allergy. 2025 Jan;80(1):77-93. 

2024

1. Leyva-Castillo JM*, Das M*, Strakosha M, McGurk A, Artru E, Kam C, Alasharee M, Wesemann DR, Tomura M, Karasuyama H, Brombacher F, Geha RS. IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation. J Allergy Clin Immunol. 2024 Dec;154(6):1462-1471. (* Co-first authors)
2. Wilkie H, Das M, Pelovitz T, Bainter W, Woods B, Alasharee M, Sobh A, Baris S, Eltan SB, Al-Herz W, Barbouche MR, Ben-Mustapha I, Ben-Ali M, Sallam MTH, Awad A, Lotfy S, El Marsafy A, Ezzelarab M, Farrar M, Schmidt BAR, NandyMazumdar M, Guttman-Yassky E, Sheets A, Vidic KM, Murphy G, Schlievert PM, Chou J, Leyva-Castillo JM, Janssen E, Timilshina M, Geha RS. Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency. J Allergy Clin Immunol. 2024 Jul;154(1):143-156. 
3. Das M, Mukherjee S, Geha RS. Phosphodiesterase 4 Inhibitors, Basophils, and Atopic Dermatitis. J Invest Dermatol. 2024 May;144(5):924-926. 

2023

1. Wilkie H, Timilshina M, Rahmayanti S, Das M, Pelovitz T, Geha RS. DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection. Clin Immunol. 2023 Sep;254:109681. 
2. Yang B, Wilkie H, Das M, Timilshina M, Bainter W, Woods B, Daya M, Boorgula MP, Mathias RA, Lai P, Petty CR, Weller E, Harb H, Chatila TA, Leung DYM, Beck LA, Simpson EL, Hata TR, Barnes KC, Phipatanakul W, Leyva-Castillo JM, Geha RS. The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice. J Allergy Clin Immunol. 2023 May;151(5):1296-1306.

2021

1. Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI Insight. 2021 Nov 8;6(21):e149953
2. Bainter W, Lougaris V, Wallace JG, Badran Y, Hoyos-Bachiloglu R, Peters Z, Wilkie H, Das M, Janssen E, Beano A, Farhat KB, Kam C, Bercich L, Incardona P, Villanacci V, Bondioni MP, Meini A, Baronio M, Abarzua P, Parolini S, Tabellini G, Maio S, Schmidt B, Goldsmith JD, Murphy G, Hollander G, Plebani A, Chou J, Geha RS. Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα). Sci Immunol. 2021 Sep 17;6(63):eabf6723. 
3. Das M, Leyva-Castillo JM, Geha RS. Basophil: The cell that itches. J Allergy Clin Immunol. 2021 Sep;148(3):708-709.
4. Leyva-Castillo JM, Das M, Artru E, Yoon J, Galand C, Geha RS. Mast cell-derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure. J Allergy Clin Immunol. 2021 Jun;147(6):2305-2315.

2020

1. Stephen-Victor E, Das M, Karnam A, Pitard B, Gautier JF, Bayry J. Potential of regulatory T-cell-based therapies in the management of severe COVID-19. Eur Respir J. 2020 Sep 3;56(3):2002182. 
2. Janssen E, Tohme M, Butts J, Giguere S, Sage PT, Velázquez FE, Kam C, Milin E, Das M, Sobh A, Al-Tamemi S, Luscinskas FW, Batista F, Geha RS. DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 Aug 6;5(15):e134508.
3. Das M, Stephen-Victor E, Bayry J. Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms. Oncoimmunology. 2020 Jun 5;9(1):1773193. 
4. Karnam A, Rambabu N, Das M, Bou-Jaoudeh M, Delignat S, Käsermann F, Lacroix-Desmazes S, Kaveri SV, Bayry J. Therapeutic normal IgG intravenous immunoglobulin activates Wnt-β-catenin pathway in dendritic cells. Commun Biol. 2020 Mar 4;3(1):96.
5. Galeotti C, Karnam A, Das M, Kaveri SV, Bayry J. Acid Stripping of Surface IgE Antibodies Bound to FcεRI is Unsuitable for the Functional Assays that Require Long-Term Culture of Basophils and Entire Removal of Surface IgE. Int J Mol Sci. 2020 Jan 13;21(2):510. 
6. Das M, Karnam A, Stephen-Victor E, Gilardin L, Bhatt B, Kumar Sharma V, Rambabu N, Patil V, Lecerf M, Käsermann F, Bruneval P, Narayanaswamy Balaji K, Benveniste O, Kaveri SV, Bayry J. Intravenous immunoglobulin mediates anti-inflammatory effects in peripheral blood mononuclear cells by inducing autophagy. Cell Death Dis. 2020 Jan 23;11(1):50. 

2019

1. Galeotti C, Stephen-Victor E, Karnam A, Das M, Gilardin L, Maddur MS, Wymann S, Vonarburg C, Chevailler A, Dimitrov JD, Benveniste O, Bruhns P, Kaveri SV, Bayry J. Intravenous immunoglobulin induces IL-4 in human basophils by signaling through surface-bound IgE. J Allergy Clin Immunol. 2019 Aug;144(2):524-535.
2. Ray S, Da Costa R, Das M, Nandi D. Interplay of cold shock protein E with an uncharacterized protein, YciF, lowers porin expression and enhances bile resistance in Salmonella Typhimurium. J Biol Chem. 2019 Jun 7;294(23):9084-9099. 
3. Karnam A, Stephen-Victor E, Das M, Magy L, Vallat JM, Bolgert F, Simon-Loriere E, Kaveri SV, Sakuntabhai A, Bayry J. Does intravenous immunoglobulin therapy in Guillain-Barré syndrome patients interfere with serological Zika detection? Autoimmun Rev. 2019 Jun;18(6):632-633. 
4. Mukherjee S, Karnam A, Das M, Babu SPS, Bayry J. Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4. Commun Biol. 2019 May 7;2:169.
5. Das M, Alzaid F, Bayry J. Regulatory T Cells under the Mercy of Mitochondria. Cell Metab. 2019 Feb 5;29(2):243-245.

2018

1. Sharma M*, Das M*, Stephen-Victor E, Galeotti C, Karnam A, Maddur MS, Bruneval P, Kaveri SV, Bayry J. Regulatory T cells induce activation rather than suppression of human basophils. Sci Immunol. 2018 May 25;3(23):eaan0829. (* Co-first authors)

2017

1. Stephen-Victor E, Karnam A, Fontaine T, Beauvais A, Das M, Hegde P, Prakhar P, Holla S, Balaji KN, Kaveri SV, Latgé JP, Aimanianda V, Bayry J. Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells. J Infect Dis. 2017 Dec 5;216(10):1281-1294. 
2. Stephen-Victor E*, Das M*, Sharma M, Galeotti C, Fohrer-Ting H, Sendid B, Darnige L, Terris B, Badoual C, Bruneval P, Kaveri SV, Bayry J. Demystification of enigma on antigen-presenting cell features of human basophils: data from secondary lymphoid organs. Haematologica. 2017 Jun;102(6):e233-e237. (* Co-first authors)
3. Maddur MS*, Stephen-Victor E*, Das M*, Prakhar P, Sharma VK, Singh V, Rabin M, Trinath J, Balaji KN, Bolgert F, Vallat JM, Magy L, Kaveri SV, Bayry J. Regulatory T cell frequency, but not plasma IL-33 levels, represents potential immunological biomarker to predict clinical response to intravenous immunoglobulin therapy. J Neuroinflammation. 2017 Mar 20;14(1):58. (* Co-first authors)
4. Das M, Galeotti C, Stephen-Victor E, Karnam A, Kaveri SV, Bayry J. Human basophils may not undergo modulation by DC-SIGN and mannose receptor-targeting immunotherapies due to absence of receptors. J Allergy Clin Immunol. 2017 Apr;139(4):1403-1404.
5. Saha C*, Das M*, Patil V, Stephen-Victor E, Sharma M, Wymann S, Jordi M, Vonarburg C, Kaveri SV, Bayry J. Monomeric Immunoglobulin A from Plasma Inhibits Human Th17 Responses In Vitro Independent of FcαRI and DC-SIGN. Front Immunol. 2017 Mar 14;8:275. (* Co-first authors)

2016

1. Stephen-Victor E, Sharma VK, Das M, Karnam A, Saha C, Lecerf M, Galeotti C, Kaveri SV, Bayry J. IL-1β, But Not Programed Death-1 and Programed Death Ligand Pathway, Is Critical for the Human Th17 Response to Mycobacterium tuberculosis. Front Immunol. 2016 Nov 4;7:465. 
2. Saha C*, Das M*, Stephen-Victor E, Friboulet A, Bayry J, Kaveri SV. Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4⁺ T Cell Responses. Molecules. 2016 Jul 14;21(7):912. (* Co-first authors)
3. Bhaskarla C, Das M, Verma T, Kumar A, Mahadevan S, Nandi D. Roles of Lon protease and its substrate MarA during sodium salicylate-mediated growth reduction and antibiotic resistance in Escherichia coli. Microbiology (Reading). 2016 May;162(5):764-776. 
4. Galeotti C, Hegde P, Das M, Stephen-Victor E, Canale F, Muñoz M, Sharma VK, Dimitrov JD, Kaveri SV, Bayry J. Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin. Sci Rep. 2016 Jan 22;6:19592.

2015

1. Das M, Bhosale M, Wadhwa N, Ahmed SM, Bhaskarla C, Kumar A, Srinivasan N, Nandi D. Importance of Amino Acids, Gln-119 and Tyr-376, in the S1 Pocket of Escherichia coli Peptidase N in Determining Substrate Specificity. Protein Pept Lett. 2016;23(6):548-61.
2. Das M, Kaveri SV, Bayry J. Cross-presentation of antigens by dendritic cells: role of autophagy. Oncotarget. 2015 Oct 6;6(30):28527-8.
3. Chandrasekar BS, Yadav S, Victor ES, Majumdar S, Deobagkar-Lele M, Wadhwa N, Podder S, Das M, Nandi D. Interferon-gamma and nitric oxide synthase 2 mediate the aggregation of resident adherent peritoneal exudate cells: implications for the host response to pathogens. PLoS One. 2015 Jun 1;10(6):e0128301.

2013

Bhosale M, Kumar A, Das M, Bhaskarla C, Agarwal V, Nandi D. Catalytic activity of Peptidase N is required for adaptation of Escherichia coli to nutritional downshift and high temperature stress. Microbiol Res. 2013 Jan 15;168(1):56-64.