Dr. Snehasis Mishra

Drug delivery, microfluidics-based detection technologies, cancer biology

A. Nano-Theranostics and Microfluidics-based disease detection:

• Snehasis Mishra, Kaustav das, Sujan Chatterjee, Panchanan Saho, Sudip Kundu, Mrinal Pal, Asim Bhaumik, and Chandan Kumar Ghosh* (First author). Facile and Green Synthesis of Novel Fluorescent Carbon Quantum Dots and Their Silver Heterostructure: An In Vitro Anticancer Activity and Imaging on Colorectal Carcinoma. ACS Omega. 2023. https://doi.org/10.1021/acsomega.2c04964
• Sudip Kundu, Pulak Jana, Panchanan Sahoo, Sourav Kumar Nandi, Snehasis Mishra, Roshni Begum, Moisilee Dutta, Asiful H Seikh, Krishnananda Chattopadhyay, Chandan Kumar Ghosh. Curcumin-based Nanoformulation for the Pyroptotic Death of MDA- MB-231 Cells. ACS Applied Nano Materials. 2024. https://doi.org/10.1021/acsanm.3c05662
• Anish Pal*, Snehasis Mishra*, Arani Mukhopadhyay, Atique Ahmed, Constantine M. Megaridis (*joint first authors), Novel glass based Microfluidic device for Enhanced Cancer Cell Detection. Advanced Functional Materials, https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/adfm.202524446 (*joint first authors)
• Pulak Jana, Sudip Kundu, Rajdip Roy, Dwipanjan Sanyal,  Chandan Kumar Ghosh, Snehasis Mishra, Krishnananda Chattopadhyay (Co-corresponding author), Lipoic Acid Coated Gold Nanoparticles Prevent the Amyloid Aggregation of SOD1 Mutants in Amyotrophic Lateral Sclerosis. ACS Applied Nano Materials, 2026. Just accepted
• Panchanan Sahoo, Dipesh Choudhury, Sudip Kundu, Snehasis Mishra, Abhishek Mukherjee, Chandan Kumar Ghosh. Nanoparticles in Biomedical Applications: MRI Contrast Agents. Advanced Nanomaterials and Their Applications, CRC Press. 2023. eBook ISBN9781003323518
• Panchanan Sahoo, Pulak Jana, Sudip Kundu, Snehasis Mishra, Krishnananda Chattopadhyay, Abhishek Mukherjee, Chandan Kumar Ghosh. Quercetin@Gd3+ doped Prussian blue nanocubes induce the pyrop- totic death of MDA-MB-231 cells: combinational targeted multimodal therapy, dual modal MRI, intuitive modelling of r1–r2 relaxivities. Journal of Materials Chemistry B. 2023. https://doi.org/10.1039/D3TB00316G
• Panchanan Sahoo, Sudip Kundu, Shubham Roy, S. K. Sharma, Jiten Ghosh, Snehasis Mishra, Abhishek Mukherjee and Chandan Kumar Fundamental understanding of the size and surface modification effects on r1, the relaxivity of Prussian blue nanocube@m-SiO2: a novel targeted chemo-photodynamic theranostic agent to treat colon cancer. RSC Adv. 2022. DOI: 10.1039/D2RA03995H
• Sujan Chatterjee, Snehasis Mishra, Kaustav Dutta Chowdhury, Chandan Kumar Ghosh, Krishna Das Saha (joint First Author). Analysis of various diagnostic, Therapeutics as well as immunization strategies based on nanotechnology against Covid-19 pandemic: an Interdisciplinary View. Life Sciences. 2021
• Snehasis Mishra, Krishnendu Manna, Utpal Kayal, Moumita Saha, Sauvik Chatterjee, Debraj Chandra, Michikazu Hara, Sriparna Datta, Asim Bhaumik, Krishna Das Saha (First author). Folic acid-conjugated magnetic mesoporous silica nanoparticles loaded with quercetin: a Theranostic approach for cancer RSC Adv. 2020. DOI: 10.1039/D0RA00664E
• Ujjal Das, Sunil Kc, Snehasis Mishra, Mathummal Sudarshan, Krishna Das Saha, Sanjit Dey, Anindita Chakraborty, Y Narayana. Synthesis of a novel glucose capped gold Nanoparticles as a better Theranostic candidate. PLOS ONE. 2017. https://doi.org/10.1371/journal.pone.0178202
• Ramesh Nandi*, Snehasis Mishra*, Tuhin Kumar Maji, Krishnendu Manna, Prasenjit Kar, Saswati Banerjee, Shreyasi Dutta, SK Sharma, Peter Lemmens, Krishna Das Saha, Samir Kumar Pal (*joint first authors). A novel nanohybrid for cancer theranostics: folate sensitized Fe2O3 nanoparticles for colorectal cancer diagnosis and photodynamic therapy. J. Mater. Chem. B. 2017. DOI https://doi.org/10.1039/C6TB03292C

B. Cancer Therapeutics and Chemo-resistant:

• Heba Ali, Ningjia Zhou, Li Chen, Levi vanHijfte, Vivekanudeep Karri, Yalu Zhou, Karl Habashy, Victor A. Arrieta, Kwang-Soo Kim, Joseph Duffy, Ragini Yeeravalli, Deanna M. Tiek, Xiao Song, Snehasis Mishra, Catalina Lee chang, Atique U. Ahmed, Dieter Henrik Heiland, Adam M. Sonabend, Crismita Dmello. Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas. Neuro-Oncology. 2025. https://doi.org/10.1093/neuonc/noaf227
• Snehasis Mishra, Achinta Sannigrahi, Santu Ruidas, Sujan Chatterjee, Kamalesh Roy,Deblina Misra, Barun Kumar Maity, Rabindranath Paul, Chandan Kumar Ghosh,Krishna Das Saha,* Asim Bhaumik,* and Krishnananda Chattopadhyay*. Small-Wiley, 2024 (First author). Conformational Switch of a Peptide Provides a Novel Strategy to Design Peptide Loaded Porous Organic Polymer for Pyroptosis Pathway Mediated Cancer Therapy. Small- Wiley. 2024. https://doi.org/10.1002/smll.202402953
• Graysen McManus, Ella Perrault, Cheol Park, Divya Ventrapragada, Shreya Budhiraja, Killian Buechler, Amelia Stepniak, Snehasis Mishra, Jason Miska, Atique Ahmed. DNA damage sensing kinases ATR and ATM-dependent phosphorylation of RRM2 promotes protein stabilization and chemo-adaptation. Neuro- Oncology. 2023. https://doi.org/10.1093/neuonc/noad179.0421
• Sujan Chatterjee, Debajyoti Patra, Pujita Ghosh, Soumi Banerjee, Snehasis Mishra, Pratip Chakraborty, Kaustav Dutta Chowdhury, Anupam Basu, Gobinda Chandra Sadhukhan. Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis. Cellular Signalling. 2023. https://doi.org/10.1016/j.cellsig.2022.110486
• Graysen McManus, Ella Perrault, Cheol Park, Divya Ventrapragada, Shreya Budhiraja, Killian Buechler, Amelia Stepniak, Snehasis Mishra, Jason Miska, Atique Ahmed. DNA damage sensing kinases ATR and ATM-dependent phosphorylation of RRM2 promotes protein stabilization and chemo-adaptation. Neuro- Oncology. 2023. https://doi.org/10.1093/neuonc/noad179.0421
• Sujan Chatterjee, Debajyoti Patra, Pujita Ghosh, Soumi Banerjee, Snehasis Mishra, Pratip Chakraborty, Kaustav Dutta Chowdhury, Anupam Basu, Gobinda Chandra Sadhukhan. Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis. Cellular Signalling. 2023. https://doi.org/10.1016/j.cellsig.2022.110486
• Sanchaita Misra, Abu Md Ashif Ikbal, Dipanjan Bhattacharjee, Minakshi Hore, Snehasis Mishra, Sankha Karmakar, Alakendu Ghosh, Ravurushanmuk Srinivas, Abhik Das, Shivankar Agarwal, Krishna Das Saha, Prashant Bhardwaj, Ishvarlal Bhudarbhai Ubhadia, Parasar Ghosh, Sirshendu De, Onkar Nath Tiwari, Debprasad Chattopadhyay, Partha Palit. Validation of antioxidant, antiproliferative, and in vitro anti- rheumatoid arthritis activities of epigallo-catechin-rich bioactive fraction from Camellia sinensis var. assamica, Assam variety white tea, and its comparative evaluation with green tea fraction. Journal of Food Biochemistry. 2022. https://doi.org/10.1111/jfbc.14487
• Sabuj Kanti Das, Snehasis Mishra, Krishna Das Saha, Debraj Chan- dra, Michikazu Hara, Amany A Mostafa, Asim Bhaumik (Joint First Author). N-Rich, Polyphenolic Porous Organic Polymer and Its In Vitro Anti- cancer Activity on Colorectal Cancer. 2022. https://doi.org/10.3390/molecules27217326
• Tanushree Das, Snehasis Mishra, Sayoni Nag and Krishna Das Saha.Green-synthesized gold nanoparticles from black tea extract enhance the chemosensitivity of doxorubicin in HCT116 cells via a ROS-dependent pathway. RSC Adv. 2022. DOI: 10.1039/D1RA08374K
• Arif Ali*, Snehasis Mishra*, Saima Kamaal, Abdullah Alarifi, Mohd Afzal, Krishna Das Saha, Musheer Ahmad (*joint first authors). Evaluation of catacholase mimicking activity and apoptosis in human colorectal carcinoma cell line by activating mitochondrial pathway of copper (II) complex coupled with 2 - (quinolin-8- yloxy)(methyl)benzonitrile and 8-hydroxyquinoline. Bioorganic Chemistry. 2020. https://doi.org/10.1016/j.bioorg.2020.104479
• Aparna Datta*, Snehasis Mishra*, Krishnendu Manna, Krishna Das Saha, Siddhartha Mukherjee, Somenath Roy (*joint first authors). Pro-oxidant therapeutic activities of cerium oxide nanoparticles in colorectal carcinoma cells. ACS Omega. 2020. https://doi.org/10.1021/acsomega.9b04006
• Goutam Kulsi, Achinta Sannigrahi, Snehasis Mishra, Krishna Das Saha, Sriparna Datta, Partha Chattopadhyay, Krishnananda Chattopadhyay. A Novel Cyclic Mobile Transporter Can Induce Apoptosis by Facilitating Chloride    Anion    Transport   into        ACS    Omega.   2020. https://doi.org/10.1021/acsomega.0c00438
• Akhtar Alam, Snehasis Mishra, Atikur Hassan, Ranajit Bera, Sriparna Dutta, Krishna Das Saha, Neeladri Das. Triptycene-Based and Schiff-Base-Linked Porous Networks: Efficient Gas Uptake, High CO2/N2 Selectivity, and    Excellent    Antiproliferative        ACS    Omega.    2020. https://doi.org/10.1021/acsomega.9b04160
• Ujjal Das, Krishnendu Manna, Arghya Adhikary, Snehasis Mishra, Krishna Das Saha, Rakhi Dey Sharma, Biswanath Majumder, Sanjit Dey. Ferulic acid enhances the radiation sensitivity of lung and liver carcinoma cells by collapsing redox homeostasis: mechanistic involvement of Akt/p38 MAPK signalling pathway. Free Radical Research. 2019. https://doi.org/10.1080/10715762.2019.1655559
• Ayan Mukherjee*, Snehasis Mishra*, Naveen Kumar Kotla, Kr- ishnendu Manna, Swarnali Roy, Biswajit, Kundu, Debomita Bhattacharya, Krishna Das Saha, Arindam Talukdar (*joint first authors). Semisynthetic Quercetin Derivatives with Potent Antitumor Activity in Colon Carcinoma. ACS Omega. 2019. https://doi.org/10.1021/acsomega.9b00143
• Rahul Debnath, Nabanita Chatterjee, Subhadip Das, Snehasis Mishra, Dipayan Bose, Somenath Banerjee, Sujata Das, Krishna Das Saha, Durgadas Ghosh, Debasish Maiti. Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition-A comparison with only bromelain. Toxicology in Vitro. https://doi.org/10.1016/j.tiv.2018.11.004
• Sabuj Kanti Das, Snehasis Mishra, Krishnendu Manna, Utpal Kayal, Supratim Mahapatra, Krishna Das Saha, Sasanka Dalapati, GP Das, Amany A Mostafa, Asim Bhaumik. A new triazinebased π-conjugated mesoporous2D covalentorganic framework: it’s in vitro anticancer activities. Chemical communications (Cambridge, England). 2018. DOI https://doi.org/10.1039/C8CC07289B
• Bidyut Kumar Rana, Snehasis Mishra, Deblina Sarkar, Tapan Kumar Mondal, Saikat K Seth, Valerio Bertolasi, Krishna Das Saha, Christo- pher W Bielawski, Anvarhusein A Isab, Joydev Dinda. Isoelectronic Pt (II) - and Au (III)-N-Heterocyclic Carbene Com- plexes: A Structuraland Biological Comparison. New Journal of Chemistry. 2018. https://doi.org/10.1039/C8NJ01562G
• Piyali Bhanja, Snehasis Mishra, Krishnendu Manna, Krishna Das Saha, Asim Bhaumik. Porous Polymer Bearing Polyphenolic Organic Building Units as a Chemotherapeutic Agent for Cancer Treatment. ACS Omega. 2018. https://doi.org/10.1021/acsomega.7b01672
• Barnali Naskar, Ritwik Modak, DilipK Maiti, MichaelGB Drew, Antonio Bauzá,AntonioFrontera, Chitrangada Das Mukhopadhyay, Snehasis Mishra, Krishna Das Saha, Sanchita Goswami. A Schiff base platform: structures, sensing of Zn (II), PPi in aqueous Medium and Anticancer Activity. Dalton Transaction. 2017. https://doi.org/10.1039/C7DT01932G
• Piyali Bhanja*, Snehasis Mishra*, Krishnendu Manna, Arijit Mallick, Krishna Das Saha, Asim Bhaumik (*joint first authors). Covalent Organic Framework Material Bearing Phloroglucinol Building Units as a Potent Anticancer Agent. ACS Appl. Mater. Interfaces. 2017. https://doi.org/10.1021/acsami.7b07343

Application of Chemosensors in Cells:

• Mukul Bikash Maity, Suprava Bhunia, Arka Patra, Panchanan Sahoo, Snehasis Mishra, Chittaranjan Sinha. Use of diformyl-triazolo Schiff base for Zn2+ sensing and intracellular live cell imaging. Applied Organometallic Chemistry. 2023. https://doi.org/10.1002/aoc.7179
• Satadru Chatterjee, Sumanta Ghosh, Snehasis Mishra, Krishna Das Saha, Biswadip Banerji and Krishnananda Chattopadhyay. Efficient Detection of Early Events of Alpha-Synuclein Aggregation using a Cysteine Specific Hybrid Scaffold. 2019. https://doi.org/10.1021/acs.biochem.8b01161
• Anup Kumar Bhanja, Snehasis Mishra, Ketaki Kar, Kaushik Naskar, Suvendu Maity, Krishna Das Saha, Chittaranjan Sinha. Use of rhodamine-allyl Schiff base in chemodosimetric processes for total palladium estimation and application in live cell imaging. New Journal of Chemistry. DOI https://doi.org/10.1039/C8NJ04519D
• Anup Kumar Bhanja, Snehasis Mishra, Krishna Das Saha, Chittaranjan Sinha, A fluorescence ‘turn-on’ chemodosimeter for specific detection of Pd2+ by rhodamine appended Schiff base and its application in live cell imaging. Dalton Trans. 2017. https://doi.org/10.1039/C7DT01288H
• Anup Kumar Bhanja, Chiranjit Patra, Sudipa Mondal, Snehasis Mishra, Krishna Das Saha, Chittaranjan Sinha.Macrocycle aza-crown chromogenic reagent to Al³⁺ and fluorescence sensor for Zn²⁺ and Al³⁺ along with live cell application and logic operation. Sensors and Actuators B. 2017. https://doi.org/10.1016/j.snb.2017.05.178
• Anup Kumar Bhanja, Snehasis Mishra, Kaushik Naskar, Suvendu Maity, Krishna Das Saha, Chittaranjan Sinha. Specific Recognition of Cr3+ in Physiological Condition by allyl substituted appendage Rhodamine and Its Cell-Imaging Studies. Dalton Trans. 2017. https://doi.org/10.1039/C7DT03560H
• Chiranjit Patra, Anup Kumar Bhanja, Ambikesh Mahapatra, Snehasis Mishra, Krishna Das Saha, Chittaranjan Sinha. Coumarinyl thioether Schiff base as turn-on fluorescent Zn (II) sensor and the complex as chemosensor for the selective recognition of ATP along with its application in live cell RSC Adv. 2016. https://doi.org/10.1039/C6RA12369D

Mechanism of Inflammatory Disorders:

• Krishnendu Manna, Zareen S Khan, Moumita Saha, Snehasis Mishra, Nilesh Gaikwad, Jatindra Nath Bhakta, Kaushik Banerjee, Krishna Das Saha. Manjari Medika Grape Seed Extract Protects Methotrexate- Induced Hepatic Inflammation: Involvement of NF-κB/NLRP3 and Nrf2/HO-1 Signaling System. Journal of Inflammation Research. 2023. doi: 10.2147/JIR.S338888. eCollection 2023.
• Ujjyani Ghosh, Khondakar Sayef Ahammed, Snehasis Mishra*, Asim Bhaumik* (*Corresponding author). Ag Nanoparticles in Antiviral Therapeutics. Chemistry-An Asian Journal. 2022. https://doi.org/10.1002/asia.202101149
• Somenath Banerjee, Dipayan Bose, Subhadip Das, Nabanita Chatterjee, Snehasis Mishra, Krishna Das Saha Leishmania donovani infection induce Extracellular signal-regulated kinase ½ (ERK½) mediated lipid dropletgeneration in        Molecular         immunology. 2022. https://doi.org/10.1016/j.molimm.2021.12.008
• Saswati Banerjee, Niladri Mukherjee, Rahul L Gajbhiye, Snehasis Mishra, Parasuraman Jaisankar, Sriparna Datta & Krishna Das Saha. Intracellular anti-leishmanial effect of Spergulin-A, a triterpenoid saponin of Glinus oppositifolius. Infection and Drug Resistance. 2019. doi: 2147/IDR.S211721
• Krishnendu Manna*, Snehasis Mishra*, Moumita Saha, Supratim Mahapatra, Chirag Saha, Govind Yenge, Nilesh Gaikwad, Ramkrishna Pal, Dasharath Oulkar, Kaushik Banerjee, Krishna Das Saha (*joint first authors). Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: assessment of NF-κB and Nrf2 signaling system. International journal of nanomedicine. 2019. doi: 10.2147/IJN.S176013. eCollection 2019

Google Scholar link: https://scholar.google.com/citations?hl=en&user=lM3Jz2gAAAAJ